Succinylation heterogeneity in lung adenocarcinoma: from prognostic model to KLK6-driven tumor microenvironment remodeling
Our study delineates the succinylation landscape in LUAD, establishes a novel prognostic model for risk stratification and immunotherapy prediction. Meanwhile, we identified KLK6 as a potential promoter of tumor progression and immunosuppression. Targeting the succinylation pathway, particularly KLK6, may represent a promising therapeutic strategy for LUAD.
Authors
- Xuehan Zhu
- Jiaqi Ding (ORCID: https://orcid.org/0009-0006-8653-0206)
- Chuanpeng Zhang (ORCID: https://orcid.org/0000-0002-2415-2602)
- Jingyu Chen (ORCID: https://orcid.org/0000-0002-0563-9749)
- Yong Liu (ORCID: https://orcid.org/0000-0002-4048-5837)
- Jianjun Liu (ORCID: https://orcid.org/0000-0002-3255-3019)
- Yihong Wang (ORCID: https://orcid.org/0000-0003-1252-5579)
- Hui Kong (ORCID: https://orcid.org/0000-0001-9547-0408)
- Tao Yan (ORCID: https://orcid.org/0000-0001-8937-353X)
- Chenlong Zha
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Wuxi People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1718994
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00