SPP1, LYZ, and MCM5: potential diagnostic biomarkers for rheumatoid arthritis and cervical cancer comorbidity
This study successfully identified SPP1, LYZ, and MCM5 as key hub genes for the comorbidity of RA and cervical cancer. By regulating processes like inflammation, immune evasion, and cell proliferation, these genes not only have a high diagnostic potential but may also contribute to the occurrence and development of cervical cancer.
Authors
- Ruihe Wu
- Chong Gao (ORCID: https://orcid.org/0000-0001-7639-0808)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-8899-1886)
- Wenhao Wang (ORCID: https://orcid.org/0000-0002-9216-5325)
- Xiaoyang Liu (ORCID: https://orcid.org/0000-0002-5969-1390)
- Xueying Gu
- Caihong Wang (ORCID: https://orcid.org/0000-0003-0817-7946)
- Yuhui Zhao (ORCID: https://orcid.org/0000-0001-6287-8271)
- Kaili Qin (ORCID: https://orcid.org/0000-0001-9575-9279)
Institutions
- Brigham and Women's Hospital (US)
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fmed.2025.1693787
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00