Synthetic DNA co-immunization with vaccine-aligned common consensus nucleoprotein and hemagglutinin protects mice against lethal influenza infection with a single immunization
These data highlight the potential of heterologous cellular immunity induced by engineered NP immunogens to complement HA-based approaches to significantly improve challenge outcomes.
Authors
- Jacqueline D. Chu
- Jillian Eisenhauer
- Nicholas J. Tursi (ORCID: https://orcid.org/0000-0001-6752-3402)
- David B. Weiner (ORCID: https://orcid.org/0000-0002-2232-8512)
- E. Gary (ORCID: https://orcid.org/0000-0002-2928-1120)
- Ami Patel (ORCID: https://orcid.org/0000-0002-2104-9984)
- Casey E. Hojecki
- Abigail Rose Trachtman (ORCID: https://orcid.org/0000-0003-2802-5122)
- M. Tomirotti
- Ying Ye (ORCID: https://orcid.org/0009-0007-4109-847X)
- Suman Bharti
- Mengdi Zheng (ORCID: https://orcid.org/0009-0008-9679-8016)
- Jayamanna Wickramasinghe
- Dan Wang (ORCID: https://orcid.org/0000-0001-7281-4853)
- David Custodio Zegarra
Institutions
- The Wistar Institute (US)
- University of the Sciences (US)
- University of Pennsylvania (US)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1632121
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00