Deep exploration of the TCR CDR3β repertoire specific for viral CD4 T-cell epitopes inside the circulating T-cell repertoire
Overall, our data demonstrate that CD4 T-cell responses to these viral epitopes are polyclonal and highly personalized. The modest overlap of clonotypes between donors, coupled with a long tail of low-frequency clones, suggests that the full diversity of the epitope-specific T-cell repertoire is likely broader than previously estimated.
Authors
- Robert Olaso (ORCID: https://orcid.org/0000-0001-7631-9657)
- Bernard Maillère (ORCID: https://orcid.org/0000-0001-5580-4194)
- Stéphane Hua (ORCID: https://orcid.org/0000-0002-2244-5663)
- Gautier Lhomme
- Valéria Porcheddu
- Rémi Giraudet
- Evelyne Correia
Institutions
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Centre National de Recherche en Génomique Humaine (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Direction de la Recherche Fondamentale (FR)
- CEA Paris-Saclay (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1713225
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission