Absence of the LRRK2 mutation in Emirati Parkinson’s disease patients in contrast to other Arab populations
The absence of the <i>LRRK2</i> and specifically the G2019S mutation in Emirati PD patients corroborates findings from Saudi Arabia and indicates a distinct genetic pattern compared to other Arab regions like Egypt and Maghreb (North African) countries, where the G2019S mutation prevalence ranges from 10 to 40%. This underscores the need for further research to unveil alternative genetic determinants specific to the Emirati PD population.
Authors
- Nasna Nassir (ORCID: https://orcid.org/0000-0002-8883-9630)
- Tom Loney (ORCID: https://orcid.org/0000-0003-1687-6587)
- Hani T. S. Benamer (ORCID: https://orcid.org/0000-0003-1369-8746)
- К. Ray Chaudhuri (ORCID: https://orcid.org/0000-0003-2815-0505)
- Vinod Metta (ORCID: https://orcid.org/0000-0002-8970-8595)
- Anjana Soorajkumar (ORCID: https://orcid.org/0000-0002-1873-2440)
- Mohammed Jashim Uddin
Institutions
- Albert Einstein College of Medicine (US)
- King's College London (GB)
- Dubai Hospital (AE)
- Genome Canada (CA)
- Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
- King's College Hospital (GB)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fnagi.2025.1676115
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mohammed Bin Rashid University of Medicine and Health Sciences