Efferocytosis-associated genes serve as prognostic biomarkers for pancreatic ductal adenocarcinoma and identify P2RY6 as a therapeutic target
The prognostic model EFFscore exhibits remarkable predictive performance, accurately reflecting the malignant potential of PDAC. P2RY6 serves as a key oncogenic factor driver in PDAC, its targeted inhibition significantly suppresses tumor progression, highlighting its dual potential as a diagnostic biomarker and therapeutic target.
Authors
- Chuanxin Yang (ORCID: https://orcid.org/0000-0003-3829-2961)
- Puxiongzhi Wang
- Xiaoyu Yan
- Yangming Liu (ORCID: https://orcid.org/0009-0002-0742-9216)
- Weimin Wang (ORCID: https://orcid.org/0000-0002-9852-1589)
- Jian Wang (ORCID: https://orcid.org/0000-0002-2748-395X)
- Liqin Yu (ORCID: https://orcid.org/0000-0002-3602-531X)
- Sijie Zhang (ORCID: https://orcid.org/0000-0002-7165-076X)
- Xiangjun Wang (ORCID: https://orcid.org/0000-0001-6519-7893)
Institutions
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1708441
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00