Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity
Altogether, these data suggest that increased concentrations of E1 and E2 contribute, at least in part, to increased hepatic CYP3A expression and activity during pregnancy in humans.
Authors
- Ian R. Mulrenin (ORCID: https://orcid.org/0000-0002-8018-2195)
- Kim Boggess
- Muluneh M. Fashe (ORCID: https://orcid.org/0000-0003-3661-8585)
- Megan Gower
- John K. Fallon (ORCID: https://orcid.org/0000-0003-1848-0121)
- Jong‐Hwa Lee (ORCID: https://orcid.org/0000-0002-5131-0514)
- Klarissa D. Jackson (ORCID: https://orcid.org/0000-0002-9388-9800)
- Craig R. Lee (ORCID: https://orcid.org/0000-0003-3595-5301)
- Joseph T. Grieco
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fphar.2025.1702419
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00