Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence

In all, this study suggests that CeA-CRF neurons may have pro-nociceptive properties that are exacerbated by early life pain and result in maladaptive responding to subsequent traumatic events.

Authors

Michael A. Burman (ORCID: https://orcid.org/0000-0003-2308-8570)
Emma Naess
Megan Tomasch
Skyler McComas

Institutions

University of New England (US)
University of Maine (US)

Publication Details

Journal: Frontiers in Behavioral Neuroscience
Published: 2025-11-26
DOI: https://doi.org/10.3389/fnbeh.2025.1653346
Primary Topic: Stress Responses and Cortisol
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Institutes of Health

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article

Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence

Michael A. Burman, Emma Naess, Megan Tomasch, Skyler McComas

Nov 26, 2025

Frontiers in Behavioral Neuroscience

Stress Responses and Cortisol

article

Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence

Michael A. Burman, Emma Naess, Megan Tomasch, Skyler McComas

November 26, 2025article en

Abstract

In all, this study suggests that CeA-CRF neurons may have pro-nociceptive properties that are exacerbated by early life pain and result in maladaptive responding to subsequent traumatic events.

Frontiers in Behavioral NeuroscienceVol. 19

University of New England (US), University of Maine (US)

National Institutes of Health

Openalex Percentile: Top 60%

Stress Responses and Cortisol

DOI Open Access PDF OpenAlex

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Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence — Michael A. Burman, Emma Naess, et al. · Frontiers in Behavioral Neuroscience (2025) | TGRS Research Map | TGRS