Intrinsic resistance to short-tailed azoles in the basal fungus Mucor lusitanicus: functional analysis of Cyp51 isoforms and amino acid substitutions
These findings demonstrate the functional expression of MluCyp51-F1 and MluCyp51-F5 isoforms in a phylogenetically distant host and confirm that conserved substitutions Y129F and V293A in MluCyp51-F5 confer intrinsic resistance to short-tailed azoles in <i>M. lusitanicus</i>.
Authors
- Katharina Rosam (ORCID: https://orcid.org/0000-0002-4170-558X)
- Bettina Sarg (ORCID: https://orcid.org/0000-0002-4785-8739)
- Christoph Müller (ORCID: https://orcid.org/0000-0002-1163-2527)
- Mikhail V. Keniya (ORCID: https://orcid.org/0000-0001-5193-6982)
- Michaela Lackner (ORCID: https://orcid.org/0000-0001-9073-2886)
- Ulrike Binder (ORCID: https://orcid.org/0000-0002-2160-2903)
- Marija M. Stojanović
- Lisa-Maria Zenz
- Brian C. Monk (ORCID: https://orcid.org/0000-0003-2264-3480)
Institutions
- Innsbruck Medical University (AT)
- Hackensack Meridian Health (US)
- Center for Discovery (US)
- University of Otago (NZ)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fmicb.2025.1702408
- Citations
- 1
- Primary Topic
- Fungal and yeast genetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Austrian Science Fund