Phytosphingosine contributes gut microbiota metabolism to alleviate low-grade endotoxemia-induced mastitis
Collectively, our results demonstrate that gut microbiota from PS-dosed mice alleviate LGE-induced mastitis in mice by promoting SCFA production and regulating macrophage polarization. Our findings provide deeper insights into gut dysbiosis-associated mastitis and highlight the potential of modulating gut microbiota and its metabolism as a strategy for managing mastitis and other related diseases. Video Abstract.
Authors
- Caijun Zhao (ORCID: https://orcid.org/0000-0002-6435-8437)
- Chongshan Yuan (ORCID: https://orcid.org/0000-0002-9829-6537)
- Yunhe Fu (ORCID: https://orcid.org/0000-0002-3258-2610)
- Xiaoyu Hu (ORCID: https://orcid.org/0000-0002-6193-2763)
- Lijuan Bao (ORCID: https://orcid.org/0000-0001-7262-3790)
- Naisheng Zhang
- Shang Shan
- Yihong Zhao (ORCID: https://orcid.org/0000-0001-8730-0476)
- Hongyan Li
- Wenjia Li (ORCID: https://orcid.org/0000-0001-6059-6422)
- Jiawen Xu
- Yuhong He (ORCID: https://orcid.org/0009-0001-8093-8538)
- Keyi Wu
- Hang Yu
- Haiqi Li
- Min Qiu
- Jun Wang (ORCID: https://orcid.org/0000-0003-0376-6071)
Institutions
- Union Hospital (HK)
- Jilin University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s40168-025-02266-9
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00