Integrated pathway analysis identifies prognostically relevant subtypes of glioblastoma characterized by abnormalities in multi‐omics
We report the interaction between tumor cells and environmental immune cells, classifying GBM into two main subtypes: 1) The tumor-driving subtype is characterized by multiple oncogenic mutations, while 2) the immune-blockage subtype is marked by a high presence of immune cells. We used integrated multidimensional analyses of somatic mutations, DNA methylation, and RNA transcripts to gain a deeper understanding of GBM biology and potential therapeutic implications.
Authors
- Lei Dong (ORCID: https://orcid.org/0000-0001-7530-7427)
- Dan Liu (ORCID: https://orcid.org/0009-0004-6245-6027)
- Pei Zhang (ORCID: https://orcid.org/0000-0003-0608-5677)
- Yanlin Zhang (ORCID: https://orcid.org/0000-0003-4002-443X)
- Xiao–kun Ouyang (ORCID: https://orcid.org/0000-0002-8534-0279)
- Xia Qin (ORCID: https://orcid.org/0000-0002-9559-6470)
- Lu Zhong
- Tonghui Yu
Institutions
- Harbin Institute of Technology (CN)
- Ministry of Industry and Information Technology (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1002/ctm2.70517
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00