Metabolic enzyme PFKFB3 mediates matrix stiffness‐potentiated tumour growth and radiotherapeutic resistance in HCC
Increased matrix stiffness significantly promoted glycolysis in HCC cells via upregulating PFKFB3 expression. High stiffness stimulation suppressed PFKFB3 ubiquitination by downregulating E3 ubiquitin ligase NEDD4 expression. PFKFB3 participated in DNA damage repair by translocating into nuclear and interacting with Ku70, which strengthened by matrix stiffness.
Authors
- Taiwei Sun
- Kun Guo (ORCID: https://orcid.org/0000-0002-4822-5984)
- Rongxin Chen (ORCID: https://orcid.org/0000-0002-3236-5878)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-6148-5908)
- Jiefeng Cui (ORCID: https://orcid.org/0000-0001-6996-720X)
- Dongmei Gao (ORCID: https://orcid.org/0000-0003-3442-5704)
- Miao Li (ORCID: https://orcid.org/0000-0001-7840-7511)
- Jiajun Li (ORCID: https://orcid.org/0000-0001-6571-0060)
- Zhiming Wang (ORCID: https://orcid.org/0000-0002-0201-8912)
- Fan Wang (ORCID: https://orcid.org/0000-0001-8191-9657)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-3869-3856)
- Jiali Qian (ORCID: https://orcid.org/0000-0002-9651-0886)
- Zhenggang Ren (ORCID: https://orcid.org/0000-0002-2799-547X)
- Mimi Wang (ORCID: https://orcid.org/0000-0002-9727-8943)
- Yingying Zhao (ORCID: https://orcid.org/0009-0009-9166-9378)
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Shanghai Cancer Institute (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Ministry of Education (ET)
- Huashan Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1002/ctm2.70509
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China