Intrinsic Motoneuron Excitability Differentiates Sarcopenic, Nonsarcopenic and Athletic Ageing Phenotypes
Intrinsic motoneuron excitability, as estimated by ΔF, is substantially reduced in this group of sarcopenic older adults, suggesting that it may be critical to functional capacity. Long-term exercise practice preserves excitability, particularly during high-demand motor tasks. These findings identify intrinsic motoneuron excitability as both a mechanistic marker of neuromuscular ageing and a potential target for investigations of novel interventions aiming to restore neuromotor function in sarcopenia.
Authors
- Brian C. Clark (ORCID: https://orcid.org/0000-0002-6021-6431)
- Lucas B. R. Orssatto (ORCID: https://orcid.org/0000-0003-3788-3700)
- Robin M. Daly (ORCID: https://orcid.org/0000-0002-9897-1598)
- David Scott (ORCID: https://orcid.org/0000-0001-5226-1972)
- Jeffrey Lim (ORCID: https://orcid.org/0009-0002-4902-2158)
Institutions
- Deakin University (AU)
- The University of Queensland (AU)
- Ohio University (US)
- Monash Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1002/jcsm.70126
- Citations
- 2
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Deakin University
- University of Queensland
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- National Institute on Aging