Identification of Six Potential Therapeutic Targets Common to Ischemic Stroke and Vascular Dementia: Genetic Insights From an Integrated Bioinformatics Analysis
Our findings illuminate causal pathways and potential therapeutic targets for IS and VD. We identified six plasma proteins with causal relationships to IS, VD, and their risk factors, providing insights into using these proteins as therapeutic targets for IS and VD.
Authors
- Fumei Liu (ORCID: https://orcid.org/0000-0002-7614-6693)
- Yan‐Ming Xie (ORCID: https://orcid.org/0000-0001-5359-4242)
- Yan Chai (ORCID: https://orcid.org/0000-0003-1174-8615)
- Fa Lin (ORCID: https://orcid.org/0000-0001-8705-2652)
- Yi Liu (ORCID: https://orcid.org/0000-0002-7782-4548)
- Min Wang (ORCID: https://orcid.org/0000-0003-3014-4403)
- Xiaolin Chen (ORCID: https://orcid.org/0000-0001-6756-3391)
- Haiyan Xiao (ORCID: https://orcid.org/0000-0003-2878-337X)
- Guibo Sun
- Jian Lyu (ORCID: https://orcid.org/0000-0001-6518-622X)
Institutions
- University of California, Los Angeles (US)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Xiyuan Hospital (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1002/brb3.71096
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences
- National Science and Technology Major Project
- Bijzonder Onderzoeksfonds UGent
- National Key Research and Development Program of China