Regulatory mechanism of the oprM gene in colistin resistance of acinetobacter baumannii
The oprM gene is a crucial determinant of colistin resistance in AB. Its deletion restores colistin susceptibility, impairs biofilm formation, and attenuates virulence. Targeting oprM may provide a promising approach for treating colistin-resistant AB infections.
Authors
- Wenjie Li (ORCID: https://orcid.org/0000-0001-7591-4470)
- Huihuang Xu
- Yuting Wang (ORCID: https://orcid.org/0000-0002-0116-7385)
- Ling Wang (ORCID: https://orcid.org/0000-0001-9292-8989)
- Junshan Ruan (ORCID: https://orcid.org/0000-0002-6462-2357)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.jiph.2025.103068
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00