Reducing breast biopsy at MRI: comparison of minimum ADC cutoff and mean ADC cutoff identified by the ECOG-ACRIN A6702 multicenter trial
The data-derived ADC<sub>min</sub> cutoff (1.39 × 10<sup>- 3</sup>mm<sup>2</sup>/s) demonstrated non-inferiority to the ADC<sub>ACRIN</sub> cutoff in biopsy reduction while preserving sensitivity. Observed performance variations between 1.5T and 3.0T suggest that field strength and other technical factors may influence cutoff efficacy. Prospective multicenter studies with standardized protocols are needed to validate its generalisability and clarify the role of field strength.
Authors
- Fang Wu (ORCID: https://orcid.org/0000-0002-7926-4345)
- Shufeng Fan (ORCID: https://orcid.org/0000-0003-2050-5789)
- Jié He (ORCID: https://orcid.org/0000-0003-0327-8852)
- Fangyi Xu
- Xia Song
- Hongjie Hu (ORCID: https://orcid.org/0009-0003-7616-8379)
- Dongying Su (ORCID: https://orcid.org/0009-0005-5596-3837)
Institutions
- Zhejiang Chinese Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12885-025-15282-7
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00