β-Substituted Styrenes in Heteroaryl-Directed Hydroalkylative Cross-Couplings: Regio-, Diastereo-, and Enantioselective Formation of β-Stereogenic Tertiary Alcohols
Under iridium-catalyzed conditions, 2-azaaryl-substituted secondary alcohols undergo C(sp<sup>3</sup>)-H addition reactions to β-substituted styrenes to provide alkylated tertiary alcohols. The processes occur with high regio-, diastereo-, and enantioselectivity and offer unusual examples of 1,2-disubstituted styrenes engaging in α-selective and stereocontrolled C-H addition reactions.
Authors
- Wenbin Mao (ORCID: https://orcid.org/0000-0001-8746-1616)
- John F. Bower (ORCID: https://orcid.org/0000-0002-7551-8221)
- Craig M. Robertson (ORCID: https://orcid.org/0000-0002-4789-7607)
Institutions
- University of Liverpool (GB)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1021/jacs.5c17840
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00