Single‐Cell Atlas of Aging Human Skin Reveals <scp>FOSB</scp> ‐Related Transcriptional Programs and Druggable Targets
Our data showed the skin cell clusters presented distinct transcriptional signatures during skin aging. We highlighted the versatile expression profiles of metallothionein family genes and identified the aging-related signature FOSB in the aged skin. We also provided potential target resources for antiaging therapies.
Authors
- Yinv Gong
- Dongze Lyu (ORCID: https://orcid.org/0000-0002-7546-4745)
- Youcheng Zhang (ORCID: https://orcid.org/0000-0002-3386-9728)
- Renpeng Zhou (ORCID: https://orcid.org/0000-0002-4427-4404)
- Yinmin Wang (ORCID: https://orcid.org/0000-0001-9733-8742)
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Ninth People's Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1111/jocd.70569
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China