Circadian Control of Neutrophils Drives Collateral Perfusion and Stroke Outcome
Time-of-day regulation of neutrophil function critically determines collateral perfusion and stroke severity. Neutrophil-driven NETosis during the inactive phase promotes microvascular obstruction and worsens outcomes. Targeting NET formation or timing therapy could enhance collateral efficacy and offer novel chronotherapeutic opportunities for stroke treatment.
Authors
- Carmen Nieto‐Vaquero (ORCID: https://orcid.org/0009-0002-1653-9943)
- Carlos Torroja (ORCID: https://orcid.org/0000-0001-8914-3400)
- Fátima Sánchez‐Cabo (ORCID: https://orcid.org/0000-0003-1881-1664)
- Ignacio Lizasoaín (ORCID: https://orcid.org/0000-0002-6028-7379)
- Marı́a A. Moro (ORCID: https://orcid.org/0000-0003-1010-8237)
- Elga Esposito (ORCID: https://orcid.org/0000-0002-8287-2747)
- Andrea Rubio-Ponce (ORCID: https://orcid.org/0000-0002-4275-8835)
- Ana Dopazo (ORCID: https://orcid.org/0000-0002-4910-1684)
- Sergio Callejas (ORCID: https://orcid.org/0000-0003-3351-4940)
- Blanca Díaz-Benito (ORCID: https://orcid.org/0000-0002-9491-0616)
- Patricia Calleja (ORCID: https://orcid.org/0000-0003-4858-1927)
- Alejandra Aroca-Crevillén (ORCID: https://orcid.org/0000-0002-2481-0863)
- María Isabel Cuartero (ORCID: https://orcid.org/0000-0003-4728-068X)
- Francisco Javier Castro-Millán
- Sandra Vázquez‐Reyes (ORCID: https://orcid.org/0000-0002-7365-975X)
- Alicia García‐Culebras (ORCID: https://orcid.org/0000-0003-2362-0117)
- Ana Moraga (ORCID: https://orcid.org/0000-0001-6695-557X)
- Andrés Hidalgo (ORCID: https://orcid.org/0000-0001-5513-555X)
- Eng H. Lo (ORCID: https://orcid.org/0000-0002-9327-2915)
- Iván Ballesteros (ORCID: https://orcid.org/0000-0002-6246-2353)
- Eneko Merino-Casamayor (ORCID: https://orcid.org/0009-0002-8629-9949)
- Alessandra Ruíz-Sánchez (ORCID: https://orcid.org/0009-0002-4867-690X)
- Gaohong Di
- Carlos Parra-Pérez (ORCID: https://orcid.org/0009-0007-3817-1445)
- Sara Pascual El Bobakry (ORCID: https://orcid.org/0009-0009-1938-3236)
- César Core-Barrera
Institutions
- Universidad Complutense de Madrid (ES)
- Yale University (US)
- Research Institute Hospital 12 de Octubre (ES)
- Massachusetts General Hospital (US)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Centro Nacional de Biotecnología (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- I.R.C.C.S. Oasi Maria SS (IT)
- Hospital El Escorial (ES)
- Wuhan Sixth Hospital (CN)
- Universidad Carlos III de Madrid (ES)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1161/circresaha.125.326438
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.59