Motion‐Style Scalp Acupuncture Ameliorates Post‐Stroke Muscle Spasticity Through Cerebral Blood Flow Augmentation and 5‐HT <sub>2A</sub> R‐Mediated Spinal KCC2 Reactivation
These findings demonstrate that MSSA ameliorates PSS through dual mechanisms: improving cerebral blood flow to the ischemic penumbra and restoring spinal inhibitory control via 5-HT<sub>2A</sub>R-dependent KCC2 reactivation. This study not only elucidates the mechanisms of MSSA but also provides a novel therapeutic strategy for PSS management.
Authors
- Liang‐Xiao Ma (ORCID: https://orcid.org/0000-0001-9851-0225)
- Qin‐Yong Zhang
- Lin Ma (ORCID: https://orcid.org/0000-0003-0291-2954)
- Xiu‐Yan Wang
- Jianhui Zhong (ORCID: https://orcid.org/0000-0002-8887-8103)
- Fei Li (ORCID: https://orcid.org/0000-0003-2016-6422)
- Junxiang Wang (ORCID: https://orcid.org/0000-0003-0927-2195)
- Jing‐Yun Xiu
- Qian Xu (ORCID: https://orcid.org/0000-0001-8291-8728)
Institutions
- Beijing University of Chinese Medicine (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/brb3.71064
- Citations
- 1
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.38
Funders
- National Natural Science Foundation of China
- Beijing University of Chinese Medicine
- Fundamental Research Funds for the Central Universities