Impact of Elexacaftor–Tezacaftor–Ivacaftor on Muscle Composition in Cystic Fibrosis: An AI-Assisted Chest CT-Based Body Composition Analysis
Adult pwCF, particularly those undergoing ETI therapy, experience significant changes in body composition, including increased muscle mass and myosteatosis. Trends in the development of sarcopenic obesity have been observed, particularly in female pwCF. These findings emphasize the importance of comprehensive body composition assessments and targeted interventions in pwCF treated with ETI to optimize muscle mass and quality while managing adipose tissue accumulation.
Authors
- Luca Salhöfer (ORCID: https://orcid.org/0000-0002-5376-3154)
- Marcel Opitz (ORCID: https://orcid.org/0000-0001-7455-8590)
- Wolfgang Gruber (ORCID: https://orcid.org/0000-0003-2186-9269)
- René Hosch (ORCID: https://orcid.org/0000-0003-1760-2342)
- Johannes Haubold (ORCID: https://orcid.org/0000-0003-4843-5911)
- Sivagurunathan Sutharsan (ORCID: https://orcid.org/0000-0003-4069-4900)
- Christian Taube (ORCID: https://orcid.org/0000-0002-3546-1398)
- Lale Umutlu (ORCID: https://orcid.org/0000-0001-5215-7171)
- Matthias Welsner (ORCID: https://orcid.org/0000-0003-1259-8911)
- Sebastian Zensen (ORCID: https://orcid.org/0000-0003-2997-0740)
- Michael Forsting (ORCID: https://orcid.org/0000-0002-5584-9824)
- Mathias Meetschen (ORCID: https://orcid.org/0000-0002-0719-2207)
- Dirk Westhölter (ORCID: https://orcid.org/0000-0002-4603-6602)
- Felix Nensa (ORCID: https://orcid.org/0000-0002-5811-7100)
- Florian Stehling (ORCID: https://orcid.org/0000-0002-2417-2048)
- Judith Kohnke (ORCID: https://orcid.org/0009-0009-8826-3481)
- Erik Büscher (ORCID: https://orcid.org/0009-0000-2300-239X)
Institutions
- Ruhrlandklinik (DE)
- Artificial Intelligence in Medicine (Canada) (CA)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Medical Sciences
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3390/medsci13040284
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00