Gender Differences in the Relationship Between Health Literacy and Stress Among Caregivers of Older Adults with Dementia

<b>Background/Objectives:</b> This study aims to investigate the association between health literacy (HL) and stress among family caregivers of older adults with dementia. <b>Methods:</b> Older adults and their caregivers were recruited from the geriatric outpatient memory clinic of an Italian hospital. Caregiver stress was assessed using the General Health Questionnaire-12 items (GHQ-12). HL was measured using the Newest Vital Sign (NVS) and the Short Form of the Test of Functional Health Literacy in Adults (S-TOFHLA). <b>Results:</b> A total of 170 (71% females) caregivers, including spouses and offspring, were included in the analysis. According to the NVS, 53% demonstrated adequate HL, while 83% achieved adequate scores on the S-TOFHLA. The median GHQ-12 score was 15, with 48% presenting a score above 14, indicating higher stress levels; women reported significantly higher GHQ-12 scores than men. In a multivariate linear regression analysis adjusted for sex, education, and number of care tasks provided, the S-TOFHLA score showed a borderline association with the GHQ-12 score (B = -1.45; <i>p</i> = 0.064). When characteristics of the care-recipient were added to the model, the S-TOFHLA score emerged as an independent predictor of the GHQ-12 score (B = -1.41; <i>p</i> = 0.048), along with female caregiver sex and behavioral and psychological symptoms in the care-recipients. Exploratory analysis suggested that the association between HL and stress was present among male but not female caregivers. <b>Conclusions:</b> HL was associated with psychological stress in caregivers of older adults with dementia, with the relationship appearing more pronounced among male caregivers.