Synergistic Interactions Between the Quinolone-Derived Compound HT61 and Tobramycin Against a Range of Clinical Isolates of Pseudomonas aeruginosa In Vitro
The expansion of previous studies highlighting the potentiating capabilities of HT61 on/with antibiotics in vivo across a further 63 clinical isolates of P. aeruginosa in a laboratory setting further highlights the potential therapeutic benefits of HT61-tobramycin combinations in respiratory diseases associated with drug-resistant P. aeruginosa.
Authors
- M. Faure (ORCID: https://orcid.org/0000-0001-7554-0317)
- Clive Page (ORCID: https://orcid.org/0000-0002-9358-3799)
- Richard T. Amison (ORCID: https://orcid.org/0000-0002-6616-4599)
- Anna Valentina Kelis (ORCID: https://orcid.org/0009-0001-9160-367X)
- Bailey Ramsden (ORCID: https://orcid.org/0009-0003-8951-4349)
Institutions
- King's College London (GB)
Publication Details
- Journal
- Lung
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1007/s00408-025-00855-x
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King's College London
- Dr Mortimer and Theresa Sackler Foundation