The Role of Inflammatory Clusters in Gingivitis and Periodontitis

Our collective findings highlight the importance of ICs in disease progression, benefiting the modulation of immune responses and preventing further periodontal tissue destruction. By identifying specific ICs, clinicians can better predict disease progression and recurrence, ultimately improving patient outcomes through targeted interventions.Knowledge Transfer Statement:The present study discovered the role of inflammatory clusters (ICs) on the host responses in a cross-sectional setting, including immune regulation and tissue remodeling, during naturally occurring gingivitis, whereas the disease progression to periodontitis seems to be site specific. Low-ICs were more prevalent in the gingivitis-only group compared with the periodontitis group, suggesting that gingivitis sites in periodontitis patients may be at increased risk for disease progression compared with gingivitis sites in gingivitis-only patients.