Dual Transmission Dynamics of Carbapenem Resistance in Pediatric Oncology: Plasmid-Mediated and Clonal Spread of blaNDM-5 Enterobacterales
CRE bloodstream infections in pediatric oncology patients are driven by both clonal expansion and plasmid-mediated dissemination, with plasmids playing a dominant role, especially in E. coli. These findings highlight the limitations of strain-based surveillance and the need for integrated genomic and plasmid-level monitoring to inform infection control in high-risk hospital settings. A Graphical Abstract is available for this article.
Authors
- Sally Mahfouz
- Lobna Shalaby
- Ahmed Bayoumi (ORCID: https://orcid.org/0009-0000-0086-1466)
- Omneya Hassanain (ORCID: https://orcid.org/0000-0001-5912-6773)
- Mervat Elanany
- Youssef Madney (ORCID: https://orcid.org/0000-0003-0511-1562)
- Ahmed A. Sayed (ORCID: https://orcid.org/0000-0003-4044-4709)
- Deena Jalal (ORCID: https://orcid.org/0000-0001-7778-5166)
- M. A. Tolba
- Mohamed Hashem (ORCID: https://orcid.org/0009-0006-5563-765X)
- Ghada A. Ziad
- Maryam Lotfi
Institutions
- Ain Shams University (EG)
- Cairo University (EG)
- Children Cancer Hospital (EG)
Publication Details
- Journal
- Infectious Diseases and Therapy
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1007/s40121-025-01254-8
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00