Integrating explainable AI with clinical features to enhance ADHD diagnostic understanding

Integrating multimodal clinical features with transparent ML methods provides interpretable, clinically aligned insights into adult ADHD diagnosis. The combined SHAP-EDA approach identifies actionable thresholds, clarifies differential feature contributions, and highlights the importance of comorbidity and demographic context in diagnostic evaluation. These findings support a patient-centred, data-driven framework for improving diagnostic consistency in clinical practice. Future work should focus on multi-site validation and temporal analyses to assess generalisability and stability of feature influences over time.

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Publication Details

Journal
Frontiers in Psychiatry
Published
2025-11-26
DOI
https://doi.org/10.3389/fpsyt.2025.1706216
Citations
1
Primary Topic
Attention Deficit Hyperactivity Disorder
Type
article
Field-Weighted Citation Impact
1.47

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article

Integrating explainable AI with clinical features to enhance ADHD diagnostic understanding

Hafiz Muhammad Shakeel, Marios Adamou, Georgia Antoniou
1 citations
Frontiers in Psychiatry
Attention Deficit Hyperactivity Disorder
1.47
article

Integrating explainable AI with clinical features to enhance ADHD diagnostic understanding

Hafiz Muhammad Shakeel, Marios Adamou, Georgia Antoniou
article en
1 citations

Abstract

Integrating multimodal clinical features with transparent ML methods provides interpretable, clinically aligned insights into adult ADHD diagnosis. The combined SHAP-EDA approach identifies actionable thresholds, clarifies differential feature contributions, and highlights the importance of comorbidity and demographic context in diagnostic evaluation. These findings support a patient-centred, data-driven framework for improving diagnostic consistency in clinical practice. Future work should focus on multi-site validation and temporal analyses to assess generalisability and stability of feature influences over time.

Frontiers in PsychiatryVol. 16
South West Yorkshire Partnership NHS Foundation Trust (GB), Leeds Beckett University (GB)
Leeds Beckett University
Openalex Percentile: Top 13%
Attention Deficit Hyperactivity Disorder
1.47
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