Chronic IL-1 Exposure Attenuates RELA- and STAT3-Dependent Synergistic Cytokine Signaling in Prostate Cancer Cell Lines
Our work shows that IL-1/RELA and IL-6/STAT3 work in parallel to synergistically induce cytostasis. However, chronic IL-1 exposure selects for cells that attenuate IL-1/RELA signaling, subsequently attenuating IL-1/IL-6 synergy.
Authors
- Sarah Wells
- Nikkí A. Delk (ORCID: https://orcid.org/0000-0001-9482-3830)
- Olufunsho Bankole
- Shoib Sarwar Siddiqui (ORCID: https://orcid.org/0000-0002-7028-290X)
- Stephanie Akemi Yamauchi
- Vivian Liu
- Mohamed Zaky (ORCID: https://orcid.org/0009-0003-4166-9376)
- Sarah M. Greene (ORCID: https://orcid.org/0009-0004-4531-6575)
- Abas Mahammed Abdi
- Haley Dahl-Wilkie
- Rafah Falah
- Shreya Billa (ORCID: https://orcid.org/0009-0005-2277-3797)
- Chisom Mbah
- Adora Onuogu
- Rahael Javaid
Institutions
- The University of Texas at Dallas (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3390/cancers17233778
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00