Anatomical Progression of Neuropathology in <scp>FTLD</scp> ‐ <scp>TDP</scp> Type C and Linkage to Annexin <scp>A11</scp>
Neurodegeneration originates in upper cortical layers of ATL and spreads posteriorly along paralimbic mediodorsal and associative ventrolateral pathways. In normal cortex, nuclear TDP-43 is distributed throughout the cortex, whereas normal ANXA11 shows variations that largely mirror TDP-C predilection patterns. The possibility is raised that ANXA11 may be a factor in determining the distribution of TDP-C neurodegeneration. ANN NEUROL 2026;99:639-655.
Authors
- Rudolph J. Castellani (ORCID: https://orcid.org/0000-0002-5414-3184)
- Marsel Mesulam (ORCID: https://orcid.org/0000-0001-5731-851X)
- Changiz Geula (ORCID: https://orcid.org/0000-0002-9311-3295)
- Tamar Gefen (ORCID: https://orcid.org/0000-0002-2380-3100)
- Allegra Kawles (ORCID: https://orcid.org/0000-0003-3153-5350)
- Elena Barbieri (ORCID: https://orcid.org/0000-0002-7303-846X)
- Ivan Ayala (ORCID: https://orcid.org/0009-0004-6225-146X)
- Caroline N. Nelson
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/ana.78095
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00