Development and Internal Validation of a Predictive Model for Operative Management in Blunt Abdominal Trauma Using Admission Physiological and Biochemical Parameters

<b>Background:</b> Early identification of patients requiring operative management (OM) after blunt abdominal trauma is critical, yet initial physiological signs may be nonspecific. We sought to develop and internally validate an admission-based prediction model for early emergency department (ED) triage, prior to computed tomography (CT), using routinely available physiological and biochemical parameters. <b>Methods:</b> We conducted a retrospective observational study including adult patients with blunt abdominal trauma who underwent FAST and lactate testing at admission. OM was defined as any abdominal surgical intervention within 24 h to control hemorrhage or repair injury. A multivariable logistic regression model incorporating lactate, heart rate, leukocyte count, and FAST positivity was developed using complete-case data. Lactate diagnostic accuracy was assessed using ROC analysis. Internal validation was performed with 1000 bootstrap resamples. <b>Results:</b> In 81 patients with lactate results, lactate showed good discrimination for OM (AUC 0.815). At ≥3.5 mmol/L, sensitivity was 0.737 (95% CI 0.569-0.866), specificity 0.744 (0.588-0.865), LR<sup>+</sup> 2.88, and LR<sup>-</sup> 0.35. The final logistic model demonstrated an apparent AUC of 0.904 and an optimism-corrected AUC of 0.882. The full model equation and coefficients are provided for reproducibility. <b>Conclusions:</b> Admission lactate, combined with FAST and physiologic measurements, provides useful early-triage information before CT and warrants external validation in larger cohorts.

Authors

Institutions

Publication Details

Journal
Journal of Clinical Medicine
Published
2025-11-26
DOI
https://doi.org/10.3390/jcm14238379
Primary Topic
Abdominal Trauma and Injuries
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Development and Internal Validation of a Predictive Model for Operative Management in Blunt Abdominal Trauma Using Admission Physiological and Biochemical Parameters

Demián Trueba-Lozano, Carlos A. Guzmán-Martín, Fausto Sánchez‐Muñoz, Adriana Hernández-García et al.
Journal of Clinical Medicine
Abdominal Trauma and Injuries
article

Development and Internal Validation of a Predictive Model for Operative Management in Blunt Abdominal Trauma Using Admission Physiological and Biochemical Parameters

Demián Trueba-Lozano, Carlos A. Guzmán-Martín, Fausto Sánchez‐Muñoz, Adriana Hernández-García, Iván Zepeda-Quiróz, Miguel A. Vázquez-Toledo, Daniel Juárez-Villa, Alberto García-Hernández, Raúl Sampayo-Candia, Alejandro Berruecos-Romero, Belén Marisol Chávez-Alba
article en

Abstract

<b>Background:</b> Early identification of patients requiring operative management (OM) after blunt abdominal trauma is critical, yet initial physiological signs may be nonspecific. We sought to develop and internally validate an admission-based prediction model for early emergency department (ED) triage, prior to computed tomography (CT), using routinely available physiological and biochemical parameters. <b>Methods:</b> We conducted a retrospective observational study including adult patients with blunt abdominal trauma who underwent FAST and lactate testing at admission. OM was defined as any abdominal surgical intervention within 24 h to control hemorrhage or repair injury. A multivariable logistic regression model incorporating lactate, heart rate, leukocyte count, and FAST positivity was developed using complete-case data. Lactate diagnostic accuracy was assessed using ROC analysis. Internal validation was performed with 1000 bootstrap resamples. <b>Results:</b> In 81 patients with lactate results, lactate showed good discrimination for OM (AUC 0.815). At ≥3.5 mmol/L, sensitivity was 0.737 (95% CI 0.569-0.866), specificity 0.744 (0.588-0.865), LR<sup>+</sup> 2.88, and LR<sup>-</sup> 0.35. The final logistic model demonstrated an apparent AUC of 0.904 and an optimism-corrected AUC of 0.882. The full model equation and coefficients are provided for reproducibility. <b>Conclusions:</b> Admission lactate, combined with FAST and physiologic measurements, provides useful early-triage information before CT and warrants external validation in larger cohorts.

Journal of Clinical MedicineVol. 14(23)
Mexican Social Security Institute (MX), Universidad Autónoma Metropolitana (MX), Universidad de Puebla (MX), Hospital General De Zona (MX), Instituto Nacional de Cardiología (MX), Clínica Ruiz (MX), Instituto Politécnico Nacional (MX)
Openalex Percentile: Top 44%
Abdominal Trauma and Injuries
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.