Development and Internal Validation of a Predictive Model for Operative Management in Blunt Abdominal Trauma Using Admission Physiological and Biochemical Parameters
<b>Background:</b> Early identification of patients requiring operative management (OM) after blunt abdominal trauma is critical, yet initial physiological signs may be nonspecific. We sought to develop and internally validate an admission-based prediction model for early emergency department (ED) triage, prior to computed tomography (CT), using routinely available physiological and biochemical parameters. <b>Methods:</b> We conducted a retrospective observational study including adult patients with blunt abdominal trauma who underwent FAST and lactate testing at admission. OM was defined as any abdominal surgical intervention within 24 h to control hemorrhage or repair injury. A multivariable logistic regression model incorporating lactate, heart rate, leukocyte count, and FAST positivity was developed using complete-case data. Lactate diagnostic accuracy was assessed using ROC analysis. Internal validation was performed with 1000 bootstrap resamples. <b>Results:</b> In 81 patients with lactate results, lactate showed good discrimination for OM (AUC 0.815). At ≥3.5 mmol/L, sensitivity was 0.737 (95% CI 0.569-0.866), specificity 0.744 (0.588-0.865), LR<sup>+</sup> 2.88, and LR<sup>-</sup> 0.35. The final logistic model demonstrated an apparent AUC of 0.904 and an optimism-corrected AUC of 0.882. The full model equation and coefficients are provided for reproducibility. <b>Conclusions:</b> Admission lactate, combined with FAST and physiologic measurements, provides useful early-triage information before CT and warrants external validation in larger cohorts.
Authors
- Demián Trueba-Lozano
- Carlos A. Guzmán-Martín (ORCID: https://orcid.org/0000-0001-7365-9023)
- Fausto Sánchez‐Muñoz (ORCID: https://orcid.org/0000-0001-6556-1632)
- Adriana Hernández-García (ORCID: https://orcid.org/0000-0002-0820-1734)
- Iván Zepeda-Quiróz
- Miguel A. Vázquez-Toledo (ORCID: https://orcid.org/0009-0004-3980-3377)
- Daniel Juárez-Villa
- Alberto García-Hernández
- Raúl Sampayo-Candia
- Alejandro Berruecos-Romero
- Belén Marisol Chávez-Alba
Institutions
- Mexican Social Security Institute (MX)
- Universidad Autónoma Metropolitana (MX)
- Universidad de Puebla (MX)
- Hospital General De Zona (MX)
- Instituto Nacional de Cardiología (MX)
- Clínica Ruiz (MX)
- Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- Journal of Clinical Medicine
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3390/jcm14238379
- Primary Topic
- Abdominal Trauma and Injuries
- Type
- article
- Field-Weighted Citation Impact
- 0.00