Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study
In this multicenter study of patients seen at referral centers for transthyretin cardiac amyloidosis, diagnosis in a more recent era was associated with improved survival, while tafamidis benefits were attenuated by disease severity and older age. Significant residual mortality risk remains in treated patients at higher disease stages.
Authors
- Mazen Hanna (ORCID: https://orcid.org/0000-0002-7251-3003)
- Brett W. Sperry (ORCID: https://orcid.org/0000-0002-8210-6401)
- Yuanzi Zhao
- Pranav Chandrashekar (ORCID: https://orcid.org/0000-0002-2249-1299)
- Lauren Ives (ORCID: https://orcid.org/0000-0001-5671-9557)
- Mathew S. Maurer (ORCID: https://orcid.org/0000-0001-5400-5008)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Brent Medoff (ORCID: https://orcid.org/0000-0002-3631-3696)
- Sergio Teruya (ORCID: https://orcid.org/0000-0002-4653-9330)
- Prem Soman (ORCID: https://orcid.org/0000-0003-1425-6536)
- Xiaofeng Wang (ORCID: https://orcid.org/0000-0001-8212-6931)
- Alfonsina Mirabal Santos (ORCID: https://orcid.org/0009-0009-4498-2396)
- Priyanka Bhattacharya (ORCID: https://orcid.org/0000-0001-6922-7084)
- A. Ejaz (ORCID: https://orcid.org/0009-0002-9744-8815)
- Yanjun Wu
Institutions
- Cleveland Clinic (US)
- Oregon Health & Science University (US)
- Columbia University Irving Medical Center (US)
- American Heart Institute (CY)
- University of Pittsburgh Medical Center (US)
- Saint Luke's Hospital (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1161/jaha.125.042530
- Citations
- 1
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.81