An Ex Vivo Model of Intervertebral Disc Degeneration for Assessing Retention of Injectable Cell‐Based Grafts
We developed an ex vivo IVD model with a controlled and physiologically relevant environment and used it for assessing the retention of cell-based therapies for NP repair. The model recapitulated the progression of IVD degeneration, establishing its value as a preclinical research tool and reducing the reliance on animal studies during the early translational phase.
Authors
- Jessica Schäper
- Karoliina Pelttari
- Günther Schäfer
- Andrea Barbero (ORCID: https://orcid.org/0000-0001-5252-789X)
- Francesco Santini (ORCID: https://orcid.org/0000-0001-6984-4816)
- Elias Schulze
- Stefan Schären
- Olga Krupková (ORCID: https://orcid.org/0000-0002-2041-8557)
- Arne Mehrkens (ORCID: https://orcid.org/0000-0002-9189-4278)
- Raphael Schmid
- Iván Martín (ORCID: https://orcid.org/0000-0001-6493-0432)
- Simona Negoias (ORCID: https://orcid.org/0000-0001-9435-8860)
- A. Sirek
- Janhavi Apte
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/jsp2.70144
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00