Diagnostic and Prognostic Value of High‐Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy
Hs-TnT elevation after ICI therapy is associated with increased risk of cardiac events, particularly in ICIrM, and a graded prognostic association depending on the cause of hs-TnT elevation. Identifying the underlying cause and troponin thresholds may guide risk stratification and management.
Authors
- Laura M. Koepke
- Milagros Pereyra (ORCID: https://orcid.org/0000-0003-4695-8436)
- Kwan Lee (ORCID: https://orcid.org/0000-0001-6302-9925)
- Christopher N. Kanaan (ORCID: https://orcid.org/0009-0002-3814-3501)
- Courtney Kenyon (ORCID: https://orcid.org/0009-0007-8511-4347)
- Reza Arsanjani (ORCID: https://orcid.org/0000-0001-7081-4286)
- Isabel G. Scalia (ORCID: https://orcid.org/0000-0002-6459-9767)
- Ahmed Mahmoud (ORCID: https://orcid.org/0009-0009-9729-9961)
- Barbara S. Novais
- Carolyn Larsen (ORCID: https://orcid.org/0000-0001-6530-3545)
- Kamal Awad (ORCID: https://orcid.org/0000-0001-6707-1629)
- Juan Farina (ORCID: https://orcid.org/0000-0002-5824-8485)
- Hemalatha Narayanasamy (ORCID: https://orcid.org/0000-0001-8976-5138)
- Balaji Tamarappoo
- Cecilia Tagle‐Cornell
- Nima Baba Ali
- Chadi Ayoub (ORCID: https://orcid.org/0000-0001-5877-7478)
- Mohammed Tiseer Abbas
- Sandra M. Herrmann (ORCID: https://orcid.org/0000-0002-3700-4537)
Institutions
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1161/jaha.125.041680
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05