Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis

We demonstrate that IFNγ enhances the 5-LO/ALOX5-catalyzed stage of CysLT synthesis, whereas IL-13 promotes the LTC4S dependent pathway in human monocytes or macrophages. These findings suggest a potential role for these cells in driving CysLT production in acute and chronic AD lesions and may give rise for future therapeutic interventions targeting this pathway.

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Publication Details

Journal
Inflammation Research
Published
2025-11-26
DOI
https://doi.org/10.1007/s00011-025-02108-2
Primary Topic
Dermatology and Skin Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis

Sanjay Lietzau, T. Werfel, Susanne Mommert, S. Traidl et al.
Inflammation Research
Dermatology and Skin Diseases
article

Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis

Sanjay Lietzau, T. Werfel, Susanne Mommert, S. Traidl, C. Riesselmann
article en

Abstract

We demonstrate that IFNγ enhances the 5-LO/ALOX5-catalyzed stage of CysLT synthesis, whereas IL-13 promotes the LTC4S dependent pathway in human monocytes or macrophages. These findings suggest a potential role for these cells in driving CysLT production in acute and chronic AD lesions and may give rise for future therapeutic interventions targeting this pathway.

Inflammation ResearchVol. 74(1)
Medizinische Hochschule Hannover (DE)
Openalex Percentile: Top 40%
Dermatology and Skin Diseases
DOIOpen Access PDFOpenAlex
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Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis — Sanjay Lietzau, T. Werfel, et al. · Inflammation Research (2025) | TGRS Research Map | TGRS