Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1
In conjunction with previous findings, the current data substantiate the role of MKP-1 as a protective factor in chondrocytes and highlight its potential as a therapeutic target for the treatment of osteoarthritis, because increased levels of cholesterol and its metabolism by CH25H and CYP7B1 are involved in the pathogenesis of OA, particularly in its obesity-associated phenotype.
Authors
- Eeva Moilanen (ORCID: https://orcid.org/0000-0002-8577-0316)
- Mari Hämäläinen (ORCID: https://orcid.org/0000-0002-6409-3758)
- Tiina Lehtola (ORCID: https://orcid.org/0000-0001-9732-7138)
- Teemu Moilanen (ORCID: https://orcid.org/0000-0003-4899-1301)
- Elina Nummenmaa (ORCID: https://orcid.org/0000-0001-7041-2375)
- Katriina Vuolteenaho (ORCID: https://orcid.org/0000-0003-0017-1291)
- Antti Pemmari (ORCID: https://orcid.org/0000-0002-8187-1216)
- Ida Valjus
Institutions
- Coxa Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
Publication Details
- Journal
- Inflammation Research
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1007/s00011-025-02121-5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00