Asymmetric Synthesis of Atropisomeric Amines via Transaminase‐Catalyzed Dynamic Kinetic Resolution
Atropisomeric heterobiaryl primary amines are of significant interest in both organic and pharmaceutical chemistry. A series of transaminases have been employed to synthesize these valuable compounds with high yields (up to 98% conversion) and excellent enantioselectivities (up to ≥99% ee ) via dynamic kinetic resolution of the corresponding heterobiaryl aldehydes. This process features a Lewis acid–base interaction strategy to facilitate labilization of the stereogenic axis.
Authors
- Valentı́n Hornillos (ORCID: https://orcid.org/0000-0002-6181-9146)
- Christian M. Heckmann (ORCID: https://orcid.org/0000-0003-0107-4477)
- Gonzalo de Gonzalo (ORCID: https://orcid.org/0000-0002-0863-680X)
- Juan M. Coto‐Cid (ORCID: https://orcid.org/0000-0002-7325-1041)
- Joaquín López‐Serrano (ORCID: https://orcid.org/0000-0003-3999-0155)
- Rosario Fernández (ORCID: https://orcid.org/0000-0002-1755-1525)
- José M. Lassaletta (ORCID: https://orcid.org/0000-0003-1772-2723)
- Patricia Rodríguez‐Salamanca
- Caroline E. Paul (ORCID: https://orcid.org/0000-0002-7889-9920)
Institutions
- Instituto de Investigaciones Químicas (ES)
- Instituto de Química Orgánica General (ES)
- Universidad de Sevilla (ES)
- Delft University of Technology (NL)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/adsc.70254
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00