Evaluation of Rice Traits Containing H9N2 Subtype Avian Influenza HA Protein Before Commercialization

The H9N2 avian influenza virus (AIV) is difficult to prevent and control because of its low pathogenicity and frequent mutation. In a previous study, the HA (hemagglutinin) protein of H9N2 was expressed in a rice endosperm reactor and prepared into a subunit vaccine to immunize chickens and mice, both of which exhibited a good immunity effect. The results of the intermediate tests of the transgenic strains (AIV-1 and AIV-3) showed that the HA gene can be stably expressed. Agronomic traits, such as plant height and number of grains, were significantly optimized in the transgenic strains. Moreover, no exogenous HA genes were found in the leaves of the weeds, and it was initially determined that there was no risk of gene drift. This study provides key technical support for the commercialization of plant subunit vaccines for avian influenza viruses.

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Journal
Current Issues in Molecular Biology
Published
2025-11-26
DOI
https://doi.org/10.3390/cimb47120986
Primary Topic
Transgenic Plants and Applications
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article
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article

Evaluation of Rice Traits Containing H9N2 Subtype Avian Influenza HA Protein Before Commercialization

Xuannian Wang, Lingshu Han, E P Zhang, Zhen Hao et al.
Current Issues in Molecular Biology
Transgenic Plants and Applications
article

Evaluation of Rice Traits Containing H9N2 Subtype Avian Influenza HA Protein Before Commercialization

Xuannian Wang, Lingshu Han, E P Zhang, Zhen Hao, Yupeng Hua, Lei Zhang, Wenming Gao, Shiyuan Pan, Yongliang Lou, Yi Zhun Zhu, Fei Li, Hongyan Chu, Wenbo Cheng, Jiangnan Zhang, Gaiping Zhang, Shuangli Bian
article en

Abstract

The H9N2 avian influenza virus (AIV) is difficult to prevent and control because of its low pathogenicity and frequent mutation. In a previous study, the HA (hemagglutinin) protein of H9N2 was expressed in a rice endosperm reactor and prepared into a subunit vaccine to immunize chickens and mice, both of which exhibited a good immunity effect. The results of the intermediate tests of the transgenic strains (AIV-1 and AIV-3) showed that the HA gene can be stably expressed. Agronomic traits, such as plant height and number of grains, were significantly optimized in the transgenic strains. Moreover, no exogenous HA genes were found in the leaves of the weeds, and it was initially determined that there was no risk of gene drift. This study provides key technical support for the commercialization of plant subunit vaccines for avian influenza viruses.

Current Issues in Molecular BiologyVol. 47(12)
Peking University (CN), Henan Academy of Agricultural Sciences (CN), Henan Agricultural University (CN)
Openalex Percentile: Top 62%
Transgenic Plants and Applications
DOIOpen Access PDFOpenAlex
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Evaluation of Rice Traits Containing H9N2 Subtype Avian Influenza HA Protein Before Commercialization — Xuannian Wang, Lingshu Han, et al. · Current Issues in Molecular Biology (2025) | TGRS Research Map | TGRS