Serum CYFRA21-1 as a novel biomarker for predicting progressive pulmonary fibrosis in non-IPF interstitial lung disease, a cohort study
Elevated serum CYFRA21-1 levels independently predict the development of PPF in patients with non-IPF ILD. It is correlated with impaired pulmonary function and radiographic severity. CYFRA21-1 may serve as a valuable biomarker for early risk stratification, supporting the need for validation in prospective multicentre studies.
Authors
- Xi Chen (ORCID: https://orcid.org/0000-0002-8580-6403)
- Guoxin Zhang (ORCID: https://orcid.org/0000-0001-6406-8117)
- Hui Ma (ORCID: https://orcid.org/0000-0002-9000-3146)
- Hao Cao (ORCID: https://orcid.org/0000-0002-9872-2380)
- Wei Jia
- Ming Sun (ORCID: https://orcid.org/0009-0000-1013-8378)
Institutions
- Tianjin University (CN)
- Tianjin Chest Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12890-025-04010-3
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00