The Rac1-USP11 feedback amplification loop: a radiation-activated engine driving radioresistance in hepatocellular carcinoma
This study identifies the Rac1-USP11 reciprocal feedback loop as a novel, self-reinforcing mechanism driving radioresistance in HCC. Targeting this loop via combined Rac1-GTP/USP11 inhibition represents a promising therapeutic strategy for radiosensitizing HCC.
Authors
- Yecheng Li
- Xuan-Yu Meng (ORCID: https://orcid.org/0000-0003-1644-6552)
- Shuqun Cheng (ORCID: https://orcid.org/0000-0001-6760-7470)
- Xubiao Wei (ORCID: https://orcid.org/0000-0002-4300-9676)
- Haobo Zhang (ORCID: https://orcid.org/0000-0003-3821-9676)
- Shaohua Wei (ORCID: https://orcid.org/0000-0003-2511-1455)
- Kaixiao Zhou (ORCID: https://orcid.org/0000-0003-2273-2985)
- Yabo Jiang
- Jian Wang (ORCID: https://orcid.org/0000-0002-1409-1738)
- Yang Jiao (ORCID: https://orcid.org/0000-0002-5452-5553)
- Cao Jianping (ORCID: https://orcid.org/0000-0002-4940-1660)
- Yuhao Hu (ORCID: https://orcid.org/0000-0003-1521-7838)
- Jiahao Guo (ORCID: https://orcid.org/0000-0002-2424-6983)
Institutions
- Second Military Medical University (CN)
- Soochow University (CN)
- Jiangyin People's Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1038/s41416-025-03265-1
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions