Differential Tear Lipid Metabolomics Signatures Discriminate Superior Limbic Keratoconjunctivitis From Dry Eye Disease
Tear metabolomics distinguishes SLK from DED at the molecular level through dysregulated glycerophospholipid metabolism. In SLK, compared with controls, this dysregulation coincides with elevated sPLA2, an enzyme hydrolyzing glycerophospholipids, indicating lipid-driven inflammation.
Authors
- Jiangbo Du (ORCID: https://orcid.org/0000-0002-5717-9385)
- Chao Cheng (ORCID: https://orcid.org/0000-0003-3571-8154)
- Yonghui Gu (ORCID: https://orcid.org/0000-0002-4975-1695)
- Kaili Wu (ORCID: https://orcid.org/0000-0003-3606-683X)
- Xiuping Liu (ORCID: https://orcid.org/0000-0003-1935-950X)
- Chunxiao Wang (ORCID: https://orcid.org/0000-0001-5914-1447)
- Sihao Liu (ORCID: https://orcid.org/0000-0003-0937-2460)
- Yubin Yu
- Yan Zong
Institutions
- Sun Yat-sen University (CN)
- Suzhou Municipal Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Translational Vision Science & Technology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1167/tvst.14.11.37
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University