Promoting differentiation of human-induced pluripotent stem cells into sinoatrial node-like cells through programmed regulation of AMPK signalling pathway
Early activation and then inhibition of the AMPK signalling pathway during the differentiation process can promote hiPSC differentiation to SANLCs, which may provide a novel strategy for obtaining SANLCs for studies on SAN diseases.
Authors
- Chunyan Yang (ORCID: https://orcid.org/0000-0003-1790-3647)
- Nazha Hamdani (ORCID: https://orcid.org/0000-0002-3053-0008)
- Juyi Wan (ORCID: https://orcid.org/0000-0003-1314-1673)
- İbrahim Akın (ORCID: https://orcid.org/0000-0003-1974-6147)
- Huan Lan (ORCID: https://orcid.org/0000-0001-8027-448X)
- Lukas Cyganek (ORCID: https://orcid.org/0000-0001-9120-1382)
- Ibrahim El‐Battrawy (ORCID: https://orcid.org/0000-0002-0139-1045)
- Bin Liao (ORCID: https://orcid.org/0000-0001-8317-031X)
- Xiaobo Zhou (ORCID: https://orcid.org/0000-0002-5895-0127)
- Feng Liu (ORCID: https://orcid.org/0009-0009-8583-1287)
- Fengxu Yu (ORCID: https://orcid.org/0000-0001-9907-6096)
- Zongqian Xue
Institutions
- Heidelberg University (DE)
- University Hospitals of the Ruhr-University of Bochum (DE)
- University Hospital Heidelberg (DE)
- Southwest Medical University (CN)
- Soochow University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Zhangjiagang First People's Hospital (CN)
- Universitätsmedizin Göttingen (DE)
- German Centre for Cardiovascular Research (DE)
- St. Josef-Hospital (DE)
- University Medical Centre Mannheim (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- EP Europace
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1093/europace/euaf288
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Universität Heidelberg
- National Natural Science Foundation of China
- Bundesministerium für Bildung und Forschung
- China Scholarship Council
- Deutsche Herzstiftung
- Southwest Medical University
- Hector Stiftung