Therapeutic effect of an MRGPRX2/MRGPRB2 antagonist on LL-37-induced rosacea-like inflammation in mice
GE1111 showed promising therapeutic effects in rosacea via targeting interactions between mast cells, keratinocytes, and macrophages and inhibiting inflammatory cytokines. These findings open possibilities for developing MRGPRX2/MRGPRB2 antagonists as novel treatments for rosacea.
Authors
- Bkc Chow (ORCID: https://orcid.org/0000-0003-3390-0307)
- Mukesh Kumar (ORCID: https://orcid.org/0000-0001-8580-9332)
- Shaik Abdullah Nawabjan
- Trevor K. Wong
- K. Li
- Ye Gi Choi
Institutions
- Ningbo University (CN)
- Ningbo No. 2 Hospital (CN)
- Ningbo No.6 Hospital (CN)
- University of Hong Kong (HK)
- McMaster University (CA)
Publication Details
- Journal
- Inflammation Research
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1007/s00011-025-02144-y
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese University of Hong Kong
- Hong Kong University of Science and Technology