KAT3B acts as an oncogene in PCa by mediating the succinylation of c-Myc and promoting its stability
Our research indicates that KAT3B was highly expressed in PCa. KAT3B silencing inhibited PCa cell growth and cancer tissues growth by decreasing the succinylation and expression of c-Myc. These findings potentially contribute to novel approaches in diagnosing and treating PCa.
Authors
- Sang-Woo Cha
- Quanwei Fu
- Wei Nie (ORCID: https://orcid.org/0000-0002-3776-2047)
Institutions
- Huizhou Central People's Hospital (CN)
- Huizhou University (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12957-025-04068-7
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00