Meningoencephalitis of unknown origin in dogs under veterinary referral care in England (2017–2021): a multicenter case control study
This study provides the largest referral-based analysis of MUO cases to date, offering updated insights into breed predispositions and clinical diagnosis. This more precise characterization of the demographic factors adds valuable context for future research design, particularly in breed-focused investigations and risk stratification. By documenting current diagnostic practices used by referral specialists, this work lays the foundation for greater consistency in case recognition and offers practical guidance for structuring future MUO clinical trials.
Authors
- Thomas Brown (ORCID: https://orcid.org/0000-0001-7336-4719)
- Marco Ruggeri
- Bruno A. Lopes (ORCID: https://orcid.org/0000-0001-9698-4515)
- Sophie Adamantos (ORCID: https://orcid.org/0000-0002-9494-7793)
- Raquel Trevail
- Dan Gerard O'Neill (ORCID: https://orcid.org/0000-0003-1115-2723)
- Rita Gonçalves (ORCID: https://orcid.org/0000-0001-5420-9801)
- Thomas J. A. Cardy (ORCID: https://orcid.org/0000-0002-1966-7978)
- Marzena Stefaniuk (ORCID: https://orcid.org/0000-0003-4725-8909)
- Rodolfo Cappello (ORCID: https://orcid.org/0000-0003-2291-0403)
- Giunio Bruto Cherubini (ORCID: https://orcid.org/0000-0002-0189-382X)
- Steven De Decker (ORCID: https://orcid.org/0000-0002-2505-2152)
- Mark Lowrie (ORCID: https://orcid.org/0000-0002-4993-589X)
- Angela Fadda (ORCID: https://orcid.org/0000-0002-1384-5956)
- Anna Tauro (ORCID: https://orcid.org/0000-0003-0606-7831)
- Nicolas Granger (ORCID: https://orcid.org/0000-0002-3036-3908)
- Edward Ives (ORCID: https://orcid.org/0000-0003-0669-0420)
- Lisa Alves (ORCID: https://orcid.org/0000-0002-6855-9893)
- Yoonjoung Choi (ORCID: https://orcid.org/0000-0002-1116-0937)
- L.Z. Saunders
Institutions
- University of Pisa (IT)
- Royal Veterinary College (GB)
- University of Liverpool (GB)
- University of Cambridge (GB)
- University of Bristol (GB)
- California Animal Hospital (US)
- Willows Veterinary Centre and Referral Service (GB)
- Staffordshire County Council (GB)
- North Downs Hospital (GB)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fvets.2025.1710593
- Primary Topic
- Veterinary Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Agria Djurförsäkring
- Dogs Trust
- Goddard Space Flight Center