Molybdenum-catalyzed synthesis of 2,3-disubstituted indoles <i>via</i> imine condensation and C(sp <sup>2</sup> )–H insertion
We describe a molybdenum-catalyzed deoxygenative annulation of 2-aminobenzophenones and aldehydes to access 2,3-disubstituted indoles. The readily available substrates showed good functional group tolerance, and gram-scale indole preparation could be achieved. A mechanism involving imine condensation and Mo-carbene insertion into the C(sp<sup>2</sup>)-H bond has been proposed.
Authors
- Ronghui Huang (ORCID: https://orcid.org/0000-0003-1080-3029)
- Fen‐Er Chen (ORCID: https://orcid.org/0000-0002-6734-3388)
- Xiao Feng (ORCID: https://orcid.org/0000-0002-3055-0172)
- Yong Luo (ORCID: https://orcid.org/0000-0002-7721-3974)
- Haoke Chu (ORCID: https://orcid.org/0000-0002-6201-0912)
- Xiaofang Lv (ORCID: https://orcid.org/0000-0003-2316-4537)
- Meiying Liu (ORCID: https://orcid.org/0009-0000-9797-3690)
Institutions
- Fudan University (CN)
- Changzhou University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1039/d5cc05181a
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00