Examining the effect of universal testing and treatment strategies for HIV prevention in Zambia and South Africa: generalizing the results of the HPTN 071 (PopART) trial
PopART interventions are estimated to be more protective in the population of interest than observed in the HPTN071 sample. These results partially explain the unexpected finding in arm A, providing further support for UTT strategies for HIV prevention. This analysis also highlights the importance of considering heterogeneous treatment effects among population subgroups when measuring the overall efficacy of HIV interventions.
Authors
- Bonnie E. Shook‐Sa (ORCID: https://orcid.org/0000-0001-9506-4047)
- Nora E. Rosenberg (ORCID: https://orcid.org/0000-0002-9759-9966)
- Sizulu Moyo (ORCID: https://orcid.org/0000-0002-5296-3242)
- Khangelani Zuma (ORCID: https://orcid.org/0000-0003-4492-5083)
- Peter Bock (ORCID: https://orcid.org/0000-0003-3211-6078)
- Joseph J. Eron (ORCID: https://orcid.org/0000-0002-4938-0644)
- Helen Ayles (ORCID: https://orcid.org/0000-0003-4108-2842)
- Jessie K. Edwards (ORCID: https://orcid.org/0000-0002-1741-335X)
- Deborah Donnell (ORCID: https://orcid.org/0000-0002-0587-7480)
- Michael G. Hudgens (ORCID: https://orcid.org/0000-0002-9106-4194)
- Paul N. Zivich (ORCID: https://orcid.org/0000-0002-9932-1095)
- Richard Hayes (ORCID: https://orcid.org/0000-0002-1729-9892)
- Stephen R. Cole (ORCID: https://orcid.org/0000-0003-2117-1311)
Institutions
- Human Sciences Research Council (ZA)
- University of North Carolina at Chapel Hill (US)
- University of Cape Town (ZA)
- Stellenbosch University (ZA)
- University of Oxford (GB)
- Fred Hutch Cancer Center (US)
- London School of Hygiene & Tropical Medicine (GB)
Publication Details
- Journal
- Journal of the International AIDS Society
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/jia2.70062
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gilead Sciences
- ViiV Healthcare
- Cancer Research UK
- National Institutes of Health