Hsa-miR-423-5p selectively loaded in hypoxic exosomes reduces the sensitivity of normoxic hepatocellular carcinoma to sorafenib via autophagy
In response to the upstream factor HNRNPA1, hsa-miR-423-5p is selectively loaded into hypoxic exosomes, which then target the downstream protein TAB2 to regulate the autophagy pathway and reduce the sorafenib sensitivity of normoxic hepatocellular carcinoma cells.
Authors
- Jiao Lu (ORCID: https://orcid.org/0000-0002-2121-5962)
- Diguang Wen (ORCID: https://orcid.org/0000-0001-6178-9920)
- Hua Song (ORCID: https://orcid.org/0000-0002-5856-4787)
- Xianzhi Gao (ORCID: https://orcid.org/0000-0002-3934-982X)
- Min Zou (ORCID: https://orcid.org/0000-0002-3551-4699)
- Rui Liao (ORCID: https://orcid.org/0000-0002-0057-2792)
- Bian Shu
- Yu You (ORCID: https://orcid.org/0000-0002-0012-3276)
- Ziyi Sheng
- Zuojin Liu (ORCID: https://orcid.org/0000-0002-0775-0774)
Institutions
- Chongqing University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12935-025-04055-8
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chongqing Medical University
- Centre Scientifique et Technique du Bâtiment