WSSV-induced reversal of the malate-aspartate shuttle facilitates viral replication in shrimp hemocytes
This study demonstrates that WSSV activates the host MAS pathway to facilitate its replication and highlights the dynamic reprogramming of redox-associated mitochondrial metabolism in response to WSSV infection. The WSSV-induced reversed MAS might supply specific metabolites such as aspartate needed for virus replication or to prevent the TCA shut down.
Authors
- Han‐Ching Wang (ORCID: https://orcid.org/0000-0001-7283-4942)
- Cong-Yan Chen
- Yen Siong Ng (ORCID: https://orcid.org/0000-0003-4403-2664)
- Kuan-Lun Huang
- Fei Guo (ORCID: https://orcid.org/0000-0003-3500-1006)
- Shuwen Cheng (ORCID: https://orcid.org/0009-0006-3402-6665)
Institutions
- National Cheng Kung University (TW)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12964-025-02506-3
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Cheng Kung University
- National Science and Technology Council