Evaluating the carcinogenic potential and molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human stomach using organoids and bulk sequencing data: a multi-machine learning approach combined with computational simulation
This study suggests that TCDD may affect the pathogenesis of gastric cancer by targeting specific genes and pathways. Molecular docking simulations indicate that there is a significant binding specificity effect between TCDD and target proteins, which is key to gastric cancer development.
Authors
- Miao Tan (ORCID: https://orcid.org/0000-0003-2400-1828)
- Youfu Tian
- Ke Yan (ORCID: https://orcid.org/0000-0002-7928-3888)
- Jie Liu (ORCID: https://orcid.org/0000-0001-6988-5773)
- Bing Xiao (ORCID: https://orcid.org/0000-0002-3736-6714)
- Dongdao Ma
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1007/s12672-025-04023-8
- Primary Topic
- Toxic Organic Pollutants Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shaanxi Province