Association between uric acid to albumin ratio and all-cause mortality among United States adults: An observational study

This study aimed to investigate if the ratio of uric acid to albumin (UAR) correlates with all-cause mortality. Smooth curve fitting was employed to analyze the association between UAR and all-cause mortality; a threshold saturation effect model was utilized to identify the inflection point of UAR's impact on all-cause mortality. Furthermore, the association between UAR and all-cause mortality from heart disease was assessed using a competing risks model. This study included 25,437 male participants and 27,090 female participants. Smooth curves fitting revealed a U-shaped relationship, demonstrating a distinct inflection point for UAR and all-cause mortality, with the inflection point for females appearing earlier than for males. Kaplan-Meier curves indicated a significantly elevated risk of death in the high UAR group (1.49 < UAR < 4.65) compared to the low UAR group (0 < UAR < 1.03). UAR emerges as a robust independent prognostic indicator for all-cause mortality and could serve as a readily accessible and valuable novel inflammatory marker for identifying high-risk patients.