Preimplantation genetic testing for aneuploidy in young women with recurrent spontaneous abortion

This study aimed to investigate whether preimplantation genetic testing for aneuploidy (PGT-A) improves pregnancy outcomes in in vitro fertilization-embryo transfer (IVF-ET) cycles in patients with recurrent spontaneous abortion (RSA). A total of 216 young patients with RSA (aged <38 years) who underwent IVF were included in this study. Of these, 114 patients opted for PGT-A, comprising 64 patients with a history of embryonic chromosome abnormality (ECA) (Group A) and 50 patients without ECA (Group B). The remaining 102 patients who did not undergo PGT-A served as the Control group, including 51 patients with a history of ECA (Control A) and 51 patients without ECA (Control B). Clinical outcomes were compared between the groups. The live birth rate in Group A was significantly higher compared to Control A (P <.05), whereas no significant difference was observed between groups B and Control B (P >.05). PGT-A significantly improved clinical outcomes in RSA patients with a history of ECA, but did not show a similar benefit in those without ECA. However, owing to the retrospective nature of the analysis and potential for unmeasured confounding factors, the value of PGT-A in women with RSA warrants further investigation.